A RAB6 TO RAB11 TRANSITION IS REQUIRED FOR DENSE-CORE GRANULE AND EXOSOME BIOGENESIS IN DROSOPHILA SECONDARY CELLS.

A Rab6 to Rab11 transition is required for dense-core granule and exosome biogenesis in Drosophila secondary cells.

Secretory cells in glands and the nervous system frequently package and store proteins destined for regulated secretion in dense-core granules (DCGs), which disperse when released from the cell surface.Despite the relevance of this dynamic process to diseases such as diabetes and human neurodegenerative disorders, our mechanistic understanding is r

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Prognostic impact of reduced HER2 protein expression in post-neoadjuvant therapy resection specimens: A single institution experience and review of the literature

Background: Retesting for Human epidermal growth factor receptor-2 (HER2) in post-neoadjuvant therapy resection is variable, and data is conflicting regarding the prognostic significance of changes in HER2 Implements expression pre and post therapy.Methods: We identified 104 patients with localized HER2 IHC 3+ breast cancer who received neoadjuvant

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Niche and Interspecific Association of the Dominant Species during the Invasion of Alternanthera philoxeroides in the Yangtze River Basin, China

The effects of Medicine invasive species on the local community (e.g., structure and stability) are highly environmentally dependent.Invasions of amphibious species usually take place in both xeric and humid environments, yet they are relatively poorly understood.In this study, we analyzed the communities that were dominated by Alternanthera philox

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